Počet záznamů: 1
Individual copy number variation and extensive diversity between major MHC-DAB1 allelic lineages in the European bitterling
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SYSNO ASEP 0551782 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Individual copy number variation and extensive diversity between major MHC-DAB1 allelic lineages in the European bitterling Tvůrce(i) Talarico, L. (IT)
Bryjová, Anna (UBO-W) SAI, ORCID
Čížková, Dagmar (UBO-W) RID, SAI, ORCID
Douda, K. (CZ)
Reichard, Martin (UBO-W) RID, ORCID, SAI, SAICelkový počet autorů 5 Zdroj.dok. Immunogenetics. - : Springer - ISSN 0093-7711
Roč. 74, č. 5 (2022), s. 497-505Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova Rhodeus amarus ; MHC class IIB ; Positive selection ; Gene duplication ; MHC supertypes ; Positively selected sites Vědní obor RIV EG - Zoologie Obor OECD Marine biology, freshwater biology, limnology CEP GA19-05510S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UBO-W - RVO:68081766 UT WOS 000741229700001 EID SCOPUS 85122650049 DOI 10.1007/s00251-021-01251-4 Anotace Polymorphism of the major histocompatibility complex (MHC), DAB1 gene was characterized for the first time in the European bitterling (Rhodeus amarus), a freshwater fish employed in studies of host-parasite coevolution and mate choice, taking advantage of newly designed primers coupled with high-throughput amplicon sequencing. Across 221 genotyped individuals, we detected 1-4 variants per fish, with 28% individuals possessing 3-4 variants. We identified 36 DAB1 variants, and they showed high sequence diversity mostly located within predicted antigen-binding sites, and both global and codon-specific excess of non-synonymous mutations. Despite deep divergence between two major allelic lineages, functional diversity was surprisingly low (3 supertypes). Overall, these findings suggest the role of positive and balancing selection in promotion and long-time maintenance of DAB1 polymorphism. Further investigations will clarify the role of pathogen-mediated selection to drive the evolution of DAB1 variation. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2023 Elektronická adresa https://link.springer.com/article/10.1007%2Fs00251-021-01251-4
Počet záznamů: 1