Počet záznamů: 1
Contribution of Infectious Agents to the Development of Celiac Disease
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SYSNO ASEP 0545661 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Contribution of Infectious Agents to the Development of Celiac Disease Tvůrce(i) Sánchez, Daniel (MBU-M) RID
Hoffmanová, I. (CZ)
Szczepanková, Adéla (MBU-M)
Hábová, Věra (MBU-M) RID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDČíslo článku 547 Zdroj.dok. Microorganisms. - : MDPI
Roč. 9, č. 3 (2021)Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova celiac disease ; infections ; microbiota ; parasites ; gluten-free diet ; immune response Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP TH03010019 GA TA ČR - Technologická agentura ČR Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000633921800001 EID SCOPUS 85102050690 DOI 10.3390/microorganisms9030547 Anotace The ingestion of wheat gliadin (alcohol-soluble proteins, an integral part of wheat gluten) and related proteins induce, in genetically predisposed individuals, celiac disease (CD), which is characterized by immune-mediated impairment of the small intestinal mucosa. The lifelong omission of gluten and related grain proteins, i.e., a gluten-free diet (GFD), is at present the only therapy for CD. Although a GFD usually reduces CD symptoms, it does not entirely restore the small intestinal mucosa to a fully healthy state. Recently, the participation of microbial components in pathogenetic mechanisms of celiac disease was suggested. The present review provides information on infectious diseases associated with CD and the putative role of infections in CD development. Moreover, the involvement of the microbiota as a factor contributing to pathological changes in the intestine is discussed. Attention is paid to the mechanisms by which microbes and their components affect mucosal immunity, including tolerance to food antigens. Modulation of microbiota composition and function and the potential beneficial effects of probiotics in celiac disease are discussed. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2076-2607/9/3/547
Počet záznamů: 1