Počet záznamů: 1
Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility
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SYSNO ASEP 0544582 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility Tvůrce(i) Xing, L. (DE)
Kubik-Zahorodna, Agnieszka (UMG-J)
Namba, T. (DE)
Pinson, A. (DE)
Florio, M. (DE)
Procházka, Jan (UMG-J) ORCID
Sarov, M. (DE)
Sedláček, Radislav (UMG-J) RID
Huttner, W.B. (DE)Celkový počet autorů 9 Číslo článku e107093 Zdroj.dok. EMBO Journal. - : Wiley - ISSN 0261-4189
Roč. 40, č. 13 (2021)Poč.str. 17 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova basal progenitors ; brain evolution ; human‐ ; specific gene ; memory flexibility ; neocortex expansion Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology CEP LM2018126 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED2.1.00/19.0395 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 UT WOS 000646146900001 DOI 10.15252/embj.2020107093 Anotace Neocortex expansion during human evolution provides a basis for our enhanced cognitive abilities. Yet, which genes implicated in neocortex expansion are actually responsible for higher cognitive abilities is unknown. The expression of human-specific ARHGAP11B in embryonic/foetal mouse, ferret and marmoset neocortex was previously found to promote basal progenitor proliferation, upper-layer neuron generation and neocortex expansion during development, features commonly thought to contribute to increased cognitive abilities. However, a key question is whether this phenotype persists into adulthood and if so, whether cognitive abilities are indeed increased. Here, we generated a transgenic mouse line with physiological ARHGAP11B expression that exhibits increased neocortical size and upper-layer neuron numbers persisting into adulthood. Adult ARHGAP11B-transgenic mice showed altered neurobehaviour, notably increased memory flexibility and a reduced anxiety level. Our data are consistent with the notion that neocortex expansion by ARHGAP11B, a gene implicated in human evolution, underlies some of the altered neurobehavioural features observed in the transgenic mice, such as the increased memory flexibility, a neocortex-associated trait, with implications for the increase in cognitive abilities during human evolution. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2022 Elektronická adresa https://www.embopress.org/doi/full/10.15252/embj.2020107093
Počet záznamů: 1