Počet záznamů: 1
Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease
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SYSNO ASEP 0543753 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease Tvůrce(i) Khairnar, A. (CZ)
Rudá-Kučerová, J. (CZ)
Arab, A. (CZ)
Hadjistyllis, C. (DE)
Šejnoha Minsterová, A. (CZ)
Shang, Q. (DE)
Chovsepian, A. (DE)
Dražanová, Eva (UPT-D) RID, ORCID, SAI
Szabó, N. (HU)
Starčuk jr., Zenon (UPT-D) RID, ORCID, SAI
Rektorová, I. (CZ)
Pan-Montojo, F. (DE)Celkový počet autorů 12 Zdroj.dok. Journal of Neurochemistry. - : Wiley - ISSN 0022-3042
Roč. 158, č. 3 (2021), s. 779-797Poč.str. 19 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova alpha synuclein ; diffusion kurtosis imaging ; MRI ; Parkinson ; rotenone's disease ; tract-based spatial statistics Vědní obor RIV FS - Lékařská zařízení, přístroje a vybavení Obor OECD Medical laboratory technology (including laboratory samples analysis CEP LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF16_013/0001775 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UPT-D - RVO:68081731 UT WOS 000669590100001 EID SCOPUS 85109086671 DOI 10.1111/jnc.15449 Anotace Clinical diagnosis of Parkinson's disease (PD) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (SN) already died, and the first motor symptoms appear. Therefore, tools enabling the early diagnosis of PD are essential to identify early-stage PD patients in which neuroprotective treatments could have a significant impact. Here, we test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone, a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging. Our results show that DKI, especially kurtosis, can detect the progression of pathology-associated changes throughout the CNS. Increases in mean kurtosis were first observed in the dorsal motor nucleus of the vagus (DMV) after 2 months of exposure to rotenone and before the loss of dopaminergic neurons in the SN occurred. Remarkably, we also show that limited exposure to rotenone for 2 months is enough to trigger the progression of the disease in the absence of the environmental toxin, thus suggesting that once the first pathological changes in one region appear, they can self-perpetuate and progress within the CNS. Overall, our results show that DKI can be a useful radiological marker for the early detection and monitoring of PD pathology progression in patients with the potential to improve the clinical diagnosis and the development of neuroprotective treatments. Pracoviště Ústav přístrojové techniky Kontakt Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Rok sběru 2022 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1111/jnc.15449
Počet záznamů: 1