Počet záznamů: 1  

Developmental variability channels mouse molar evolution

  1. 1.
    0539946 - ÚEM 2021 RIV GB eng J - Článek v odborném periodiku
    Hayden, L. - Lochovská, K. - Sémon, M. - Renaud, S. - Delignette-Müller, M.L. - Vilcot, M. - Peterková, R. - Hovořáková, Mária - Pantalacci, S.
    Developmental variability channels mouse molar evolution.
    eLife. Roč. 9, feb. (2020), č. článku e50103. ISSN 2050-084X. E-ISSN 2050-084X
    Grant CEP: GA ČR(CZ) GB14-37368G; GA ČR(CZ) GA18-04859S
    Institucionální podpora: RVO:68378041
    Klíčová slova: tooth development * 3-dimensional reconstruction * phenotypic variation
    Obor OECD: Developmental biology
    Impakt faktor: 8.146, rok: 2020
    Způsob publikování: Open access
    https://elifesciences.org/articles/50103

    Do developmental systems preferentially produce certain types of variation that orient phenotypic evolution along preferred directions? At different scales, from the intra-population to the interspecific, the murine first upper molar shows repeated anterior elongation. Using a novel quantitative approach to compare the development of two mouse strains with short or long molars, we identified temporal, spatial and functional differences in tooth signaling center activity, that arise from differential tuning of the activation-inhibition mechanisms underlying tooth patterning. By tracing their fate, we could explain why only the upper first molar reacts via elongation of its anterior part. Despite a lack of genetic variation, individuals of the elongated strain varied in tooth length and the temporal dynamics of their signaling centers, highlighting the intrinsic instability of the upper molar developmental system. Collectively, these results reveal the variational properties of murine molar development that drive morphological evolution along a line of least resistance.
    Trvalý link: http://hdl.handle.net/11104/0317631

     
     
Počet záznamů: 1  

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