G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

0536535 - BFÚ 2021 RIV GB eng J - Článek v odborném periodiku
Carvalho, J. - Mergny, Jean-Louis - Salgado, G.F. - Queiroz, J.A. - Cruz, C.
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies.
Trends in Molecular Medicine. Roč. 26, č. 9 (2020), s. 848-861. ISSN 1471-4914. E-ISSN 1471-499X
Grant CEP: GA MŠMT EF15_003/0000477
Institucionální podpora: RVO:68081707
Klíčová slova: dna * telomerase * visualization * sensitivity * derivatives * instability
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 11.951, rok: 2020
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S1471491420301313?via%3Dihub

The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools ('friends', as healing anticancer drugs) and targets ('foes', within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.
Trvalý link: http://hdl.handle.net/11104/0314307