Počet záznamů: 1
New multimodal stationary phases prepared by Ugi multicomponent approach
- 1.
SYSNO ASEP 0534797 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název New multimodal stationary phases prepared by Ugi multicomponent approach Tvůrce(i) Sýkora, D. (CZ)
Záruba, K. (CZ)
Butnariu, M. (CZ)
Tatar, A. (CZ)
Pham, H. M. (CZ)
Studenovský, Martin (UMCH-V) RID, ORCID
Řezanka, P. (CZ)
Král, V. (CZ)Zdroj.dok. Journal of Separation Science. - : Wiley - ISSN 1615-9306
Roč. 43, č. 22 (2020), s. 4178-4190Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova hydrophilic interaction ; hydrophobic interaction ; ion-exchange interaction Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000575807100001 EID SCOPUS 85092157397 DOI 10.1002/jssc.202000587 Anotace Eight different stationary phases based on two aminopropyl silicas of different brands suitable for multimodal chromatography applications have been prepared by a four‐component Ugi reaction. The intention was to synthesize stationary phases significantly differing in their properties hereby demonstrating flexibility of the Ugi synthetic protocol. Diverse functional groups including a nonpolar long aliphatic chain, phenyl moiety, cholic acid scaffold, phenylboronic and monosaccharide units, charged betaine, and arginine moieties were immobilized on a silica surface. The novel sorbents were extensively characterized by elemental analysis, Raman spectroscopy, and chromatography. Considering the anchored chemical structures covalently bonded to the silica surface, reversed‐phase, hydrophilic, and ion‐exchange separation modes were expected. The chromatographic evaluation was performed directed to map the potential of the individual columns specifically in the mentioned chromatographic modes. The Ugi synthetic protocol has proven to be a simple, feasible, and versatile tool for the synthesis of sorbents of variable properties. The newly prepared stationary phases differed considerably in hydrophobicity and ion‐exchange ability. A significant influence of the supporting aminopropyl silica on the final chromatographic behavior was observed. Finally, one practical example confirming applicability of the newly prepared sorbents was demonstrated in separation of cytarabine. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2021 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1002/jssc.202000587
Počet záznamů: 1