Počet záznamů: 1
The omega-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
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SYSNO ASEP 0534257 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The omega-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach Tvůrce(i) Kosek, V. (CZ)
Heczková, M. (CZ)
Novák, F. (CZ)
Meisnerová, E. (CZ)
Nováková, Olga (FGU-C)
Zelenka, J. (CZ)
Bechyňská, K. (CZ)
Vrzáčová, N. (CZ)
Suttnar, J. (CZ)
Hlaváčková, A. (CZ)
Danková, H. (CZ)
Bratová, M. (CZ)
Dasková, N. (CZ)
Malínská, H. (CZ)
Oliyarnyk, O. (CZ)
Wohl, P. (CZ)
Bastová, H. (CZ)
Hajslová, J. (CZ)
Cahová, M. (CZ)Číslo článku 2351 Zdroj.dok. Nutrients. - : MDPI
Roč. 12, č. 8 (2020)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova home parenteral nutrition ; intestinal failure ; fish oil ; olive oil ; oxidative stress ; lipidomics ; hydroxy-fatty acids ; plasmalogens ; lipidomics Vědní obor RIV FP - Ostatní lékařské obory Obor OECD Nutrition, Dietetics Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000579708700001 EID SCOPUS 85089360250 DOI 10.3390/nu12082351 Anotace Omega-3 polyunsaturated fatty acids (omega-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered omega-3 PUFAs without (FO/-,n= 9) or with (FO/OO,n= 13) olive oil and healthy age- and sex-matched controls, (n= 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/- and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/- subcohort. The lipidome of all subjects receiving omega-3 PUFAs was enriched with lipid species containing omega-3 PUFAs (FO/->FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/-. We confirmed the protective effect of OO in PN mixtures containing omega-3 PUFAs. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/2072-6643/12/8/2351
Počet záznamů: 1