Počet záznamů: 1
Light‐activated carbon monoxide prodrugs based on bipyridyl dicarbonyl ruthenium(II) complexes
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SYSNO ASEP 0532238 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Light‐activated carbon monoxide prodrugs based on bipyridyl dicarbonyl ruthenium(II) complexes Tvůrce(i) Geri, S. (DE)
Krunclová, Tereza (UMCH-V) ORCID
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Pánek, Jiří (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCID
Hernández-Valdés, D. (CH)
Probst, B. (CH)
Alberto, R. A. (CH)
Mamat, C. (DE)
Kubeil, M. (DE)
Stephan, H. (DE)Zdroj.dok. Chemistry - A European Journal. - : Wiley - ISSN 0947-6539
Roč. 26, č. 48, SI (2020), s. 10992-11006Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova carbon monoxide ; prodrug ; light activation Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA19-01438S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000563928800001 EID SCOPUS 85089397245 DOI 10.1002/chem.202002139 Anotace Two photoactivatable dicarbonyl ruthenium(II) complexes based on an amide‐functionalised bipyridine scaffold (4‐position) equipped with an alkyne functionality or a green‐fluorescent BODIPY (boron‐dipyrromethene) dye have been prepared and used to investigate their light‐induced decarbonylation. UV/Vis, FTIR and 13C NMR spectroscopies as well as gas chromatography and multivariate curve resolution alternating least‐squares analysis (MCR‐ALS) were used to elucidate the mechanism of the decarbonylation process. Release of the first CO molecule occurs very quickly, while release of the second CO molecule proceeds more slowly. In vitro studies using two cell lines A431 (human squamous carcinoma) and HEK293 (human embryonic kidney cells) have been carried out in order to characterise the anti‐proliferative and anti‐apoptotic activities. The BODIPY‐labelled compound allows for monitoring the cellular uptake, showing fast internalisation kinetics and accumulation at the endoplasmic reticulum and mitochondria. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2021 Elektronická adresa https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202002139
Počet záznamů: 1