Počet záznamů: 1  

Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon

  1. 1.
    SYSNO ASEP0532001
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevPolarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon
    Tvůrce(i) Hampl, M. (CZ)
    Dumková, J. (CZ)
    Kavková, M. (CZ)
    Dosedělová, H. (CZ)
    Bryjová, A. (CZ)
    Zahradníček, Oldřich (UJF-V) ORCID, SAI
    Pyszko, M. (CZ)
    Macholán, M. (CZ)
    Zikmund, T. (CZ)
    Kaiser, J. (CZ)
    Buchtová, M. (CZ)
    Celkový počet autorů11
    Číslo článku572
    Zdroj.dok.Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
    Roč. 8, JUL (2020)
    Poč.str.29 s.
    Forma vydáníTištěná - P
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovasecondary palate ; SHH ; primary cilia ; skeletogenesis ; chamaleon ; reptile
    Vědní obor RIVBO - Biofyzika
    Obor OECDBiophysics
    Způsob publikováníOpen access
    Institucionální podporaUJF-V - RVO:61389005
    UT WOS000561204000001
    EID SCOPUS85089346331
    DOI10.3389/fcell.2020.00572
    AnotaceSecondary palate development is characterized by the formation of two palatal shelves on the maxillary prominences, which fuse in the midline in mammalian embryos. However, in reptilian species, such as turtles, crocodilians, and lizards, the palatal shelves of the secondary palate develop to a variable extent and morphology. While in most Squamates, the palate is widely open, crocodilians develop a fully closed secondary palate. Here, we analyzed developmental processes that underlie secondary palate formation in chameleons, where large palatal shelves extend horizontally toward the midline. The growth of the palatal shelves continued during post-hatching stages and closure of the secondary palate can be observed in several adult animals. The massive proliferation of a multilayered oral epithelium and mesenchymal cells in the dorsal part of the palatal shelves underlined the initiation of their horizontal outgrowth, and was decreased later in development. The polarized cellular localization of primary cilia and Sonic hedgehog protein was associated with horizontal growth of the palatal shelves. Moreover, the development of large palatal shelves, supported by the pterygoid and palatine bones, was coupled with the shift inMeox2,Msx1, andPax9gene expression along the rostro-caudal axis. In conclusion, our results revealed distinctive developmental processes that contribute to the expansion and closure of the secondary palate in chameleons and highlighted divergences in palate formation across amniote species.
    PracovištěÚstav jaderné fyziky
    KontaktMarkéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228
    Rok sběru2021
    Elektronická adresahttps://doi.org/10.3389/fcell.2020.00572
Počet záznamů: 1  

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