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The Uptake of Ivermectin and Its Effects in Roots, Leaves and Seeds of Soybean (Glycine max)
- 1.0531905 - ÚEB 2021 RIV CH eng J - Článek v odborném periodiku
Navrátilová, M. - Stuchlíková Raisová, L. - Moťková, Kateřina - Szotáková, B. - Skálová, L. - Langhansová, Lenka - Podlipná, Radka
The Uptake of Ivermectin and Its Effects in Roots, Leaves and Seeds of Soybean (Glycine max).
Molecules. Roč. 25, č. 16 (2020), č. článku 3655. ISSN 1420-3049. E-ISSN 1420-3049
Grant CEP: GA ČR(CZ) GA18-08452S; GA MŠMT(CZ) EF16_019/0000738
Institucionální podpora: RVO:61389030
Klíčová slova: anthelmintics * antioxidant enzymes * biotransformation * drug metabolites * isoflavonoids
Obor OECD: Biochemical research methods
Impakt faktor: 4.412, rok: 2020
Způsob publikování: Open access
http://doi.org/10.3390/molecules25163655
In recent years interest has grown in the occurrence and the effects of pharmaceuticals in the environment. The aim of this work is to evaluate the risk of fertilizing crops with manure from livestock treated with anthelmintics. The present study was designed to follow the fate of the commonly used anthelmintic drug, ivermectin (IVM) and its metabolites in soybeans (Glycine max (L.) Merr.), a plant that is grown and consumed world-wide for its high content of nutritional and health-beneficial substances. In vitro plantlets and soybean plants, cultivated in a greenhouse, were used for this purpose. Our results showed the uptake of IVM and its translocation to the leaves, but not in the pods and the beans. Four IVM metabolites were detected in the roots, and one in the leaves. IVM exposure decreased slightly the number and weight of the beans and induced changes in the activities of antioxidant enzymes. In addition, the presence of IVM affected the proportion of individual isoflavones and reduced the content of isoflavones aglycones, which might decrease the therapeutic value of soybeans. Fertilization of soybean fields with manure from IVM-treated animals appears to be safe for humans, due to the absence of IVM in beans, the food part of plants. On the other hand, it could negatively affect soybean plants and herbivorous invertebrates.
Trvalý link: http://hdl.handle.net/11104/0310536
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