Increased Power by Harmonizing Structural MRI Site Differences with the ComBat Batch Adjustment Method in ENIGMA

0531247 - ÚI 2021 RIV US eng J - Článek v odborném periodiku
Radua, J. - Vieta, E. - Shinohara, R. - Höschl, C. - Tomeček, David - Škoch, A. … celkem 111 autorů
Increased Power by Harmonizing Structural MRI Site Differences with the ComBat Batch Adjustment Method in ENIGMA.
Neuroimage. Roč. 218, September 2020 (2020), č. článku 116956. ISSN 1053-8119. E-ISSN 1095-9572
Grant ostatní: GA MŠk(CZ) LO1611
Institucionální podpora: RVO:67985807
Klíčová slova: Brain * Cortical thickness * Gray matter * Mega-analysis * Neuroimaging * Schizophrenia * Volume
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 6.556, rok: 2020
Způsob publikování: Open access

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address this heterogeneity with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power. We conducted random-effects meta-analyses, mixed-effects mega-analyses and ComBat mega-analyses to compare cortical thickness, surface area and subcortical volumes between 2897 individuals with a diagnosis of schizophrenia and 3141 healthy controls from 33 sites. Specifically, we compared the imaging data between individuals with schizophrenia and healthy controls, covarying for age and sex. The use of ComBat substantially increased the statistical significance of the findings as compared to random-effects meta-analyses. The findings were more similar when comparing ComBat with mixed-effects mega-analysis, although ComBat still slightly increased the statistical significance. ComBat also showed increased statistical power when we repeated the analyses with fewer sites. Results were nearly identical when we applied the ComBat harmonization separately for cortical thickness, cortical surface area and subcortical volumes. Therefore, we recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work. We provide easy-to-use functions in R that work even if imaging data are partially missing in some brain regions, and they can be trained with one data set and then applied to another (a requirement for some analyses such as machine learning).
Trvalý link: http://hdl.handle.net/11104/0309944