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Antibacterial activity of chitosan/collagen membranes containing red propolis extract
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SYSNO ASEP 0524090 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Antibacterial activity of chitosan/collagen membranes containing red propolis extract Tvůrce(i) Loureiro, K. C. (BR)
Barbosa, T. C. (BR)
Nery, M. (BR)
Chaud, M. V. (BR)
da Silva, C. F. (BR)
Andrade, L. N. (BR)
Corrêa, C. B. (BR)
Jäger, Alessandro (UMCH-V) RID, ORCID
Padilha, F. F. (BR)
Cardoso, J. C. (BR)
Souto, E. (PT)
Severino, P. (BR)Zdroj.dok. Pharmazie. - : Avoxa - ISSN 0031-7144
Roč. 75, 2-3 (2020), s. 75-81Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova mucoadhesive polymeric membranes ; red propolis extract ; antibacterial Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000525870800005 EID SCOPUS 85082525422 Anotace In this study we developed a mucoadhesive polymeric membrane wound dressing incorporating red propolis extract (HERP). Membranes were made using a casting method employing collagen, chitosan, polyethylene glycol (15, 20, and 30v%), and hydroethanolic extract of EtOH-H2O 70v% – 30v% (v/v) of HERP (0.5, 1.0, and 1.5%). Membranes were extensively characterized to assess the thickness, pH, morphology using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), mechanical properties, swelling, in vitro mucoadhesion, cytotoxicity, and minimum inhibitory concentration (MIC). Assessment of the thickness and mechanical properties of the membranes containing HERP revealed that the most significant thickness obtained was 40.7 μm, thermal analysis suggests suggesting the hydrogen bonds between hydroxyl groups of isoflavones and the free amine present in the region of chitosan. Cell viability decreased as the amount of HERP increased. Finally, the MICs were 7.8 and 1.9 μg.mL–1 for Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, respectively. These results were suggesting that the 0.5 % HERP membrane has the potential for future studies for wound application. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2021 Elektronická adresa https://www.ingentaconnect.com/contentone/govi/pharmaz/2020/00000075/f0020002/art00005
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