Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions

0524042 - ÚMCH 2021 RIV GB eng J - Článek v odborném periodiku
Yu, H.-P. - Liu, F.-C. - Lin, C.-Y. - Umoro, A. - Trousil, Jiří - Hwang, T.-L. - Fang, J.-Y.
Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions.
Nanomedicine. Roč. 15, č. 8 (2020), s. 773-791. ISSN 1743-5889. E-ISSN 1748-6963
Grant ostatní: AV ČR(CZ) VAJVA-19-55
Institucionální podpora: RVO:61389013
Klíčová slova: anti-inflammation * lung injury * nanoemulsion
Obor OECD: Polymer science
Impakt faktor: 5.307, rok: 2020
Způsob publikování: Omezený přístup
https://www.futuremedicine.com/doi/10.2217/nnm-2019-0407

We aimed to develop nanoemulsions containing phosphodiesterase 4 inhibitor rolipram with different droplet sizes, to evaluate the anti-inflammatory effect against activated neutrophils and a related lung injury. We prepared nanoemulsions of three different sizes, 68, 133 and 188 nm. The nanoemulsion inhibited the superoxide anion but not elastase release in primary human neutrophils. The large-sized nanoemulsions were mostly internalized by neutrophils, resulting in the reduction of intracellular Ca2+ half-life. The peripheral organ distribution of near-infrared dye-tagged nanoemulsions increased, following the decrease in droplet diameter. Rolipram entrapment into intravenous nanoemulsions ameliorated pulmonary inflammation. The smallest droplet size showed improvement, compared with the largest size. We established a foundation for the development of nanoemulsions against inflamed lung disease.
Trvalý link: http://hdl.handle.net/11104/0308431