Počet záznamů: 1
Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms
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SYSNO ASEP 0507546 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms Tvůrce(i) Krajčovič, Branislav (FGU-C) ORCID
Fajnerová, Iveta (FGU-C) RID, ORCID
Horáček, J. (CZ)
Kelemen, E. (CZ)
Kubík, Štěpán (FGU-C) RID, ORCID
Svoboda, Jan (FGU-C) RID, ORCID
Stuchlík, Aleš (FGU-C) RID, ORCIDČíslo článku e13282 Zdroj.dok. Acta Physiologica. - : Wiley - ISSN 1748-1708
Roč. 226, č. 4 (2019)Poč.str. 29 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova fMRI ; GABA interneurons ; humans ; oscillations ; psychosis ; rats Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA17-04047S GA ČR - Grantová agentura ČR NV17-30833A GA MZd - Ministerstvo zdravotnictví GA16-13399S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000475639200004 EID SCOPUS 85066900998 DOI 10.1111/apha.13282 Anotace Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. The aim of this review is to bring together convergent evidence of discoordinated brain circuits in schizophrenia at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large‐scale brain networks. We show how these aberrations could underlie deficits in cognitive control and other higher order cognitive‐behavioural functions. Converging evidence from both animal models and patients with schizophrenia is presented in an effort to gain insight into common features of deficits in the brain information processing in this disorder, marked by disruption of several neurotransmitter and signalling systems and severe behavioural outcomes. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2020 Elektronická adresa https://doi.org/10.1111/apha.13282
Počet záznamů: 1