Počet záznamů: 1
Combination of cobalt bis(dicarbollide) amino derivative and antibiotic effect on growth of staphylococcus epidermidis
- 1.
SYSNO ASEP 0503776 Druh ASEP C - Konferenční příspěvek (mezinárodní konf.) Zařazení RIV D - Článek ve sborníku Název Combination of cobalt bis(dicarbollide) amino derivative and antibiotic effect on growth of staphylococcus epidermidis Tvůrce(i) Lokočová, K. (CZ)
Vaňková, E. (CZ)
Šícha, Václav (UACH-T) RID, ORCID, SAI
Masák, J. (CZ)Celkový počet autorů 4 Zdroj.dok. Proceedings of the 6th International Conference on Chemical Technology. - Prague : Czech Society of Industrial Chemistry, 2018 / Veselý M. ; Hrdlička Z. ; Hanika J. ; Lubojacký J. - ISSN 2336-8128 - ISBN 978-80-86238-77-7 Rozsah stran s. 91-94 Edice International Conference on Chemical Technology Poč.str. 4 s. Forma vydání Tištěná - P Akce International Conference on Chemical Technology /6./ Datum konání 16.04.2018 - 18.04.2018 Místo konání Mikulov Země CZ - Česká republika Typ akce EUR Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova cobalt bis(dicarbollide) ; staphylococcus genus Vědní obor RIV CA - Anorganická chemie Obor OECD Inorganic and nuclear chemistry Institucionální podpora UACH-T - RVO:61388980 UT WOS 000461293800018 Anotace Nosocomial infections are often caused by bacteria from the Staphylococcus genus. The clinically relevant representatives of this species are Staphylococcus epidermidis and Staphylococcus aureus which grow predominantly as surface-attached stable communities known as biofilms. Cells in these biofilms are often highly resistant to antibiotics. Therefore, new antimicrobial or antibiofilm substances are still being developed. In this study, we investigated the influence of cobalt bis(dicarbollide) or its amino derivatives, and antibiotics (erythromycin, tetracycline)-alone and in combination-to determine the antimicrobial activity and the inhibition of biofilm formation against three type strains of S. epidermidis. We used a microcultivation device to determine the minimum inhibitory concentrations and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to determine the metabolic activity of the cells in biofilms. We observed the synergistic effect of cobalt bis(dicarbollide) and its amino derivatives with both the antibiotics on both the planktonic and biofilm cells. Pracoviště Ústav anorganické chemie Kontakt Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Rok sběru 2020
Počet záznamů: 1