Počet záznamů: 1
Competitive asymmetric transfer hydrogenation of 3,4-dihydroisoquinolines employing Noyori-Ikariya catalytic complexes
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SYSNO ASEP 0501216 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Competitive asymmetric transfer hydrogenation of 3,4-dihydroisoquinolines employing Noyori-Ikariya catalytic complexes Tvůrce(i) Hrdličková, R. (CZ)
Zápal, Jakub (MBU-M)
Václavíková Vilhanová, B. (CZ)
Bugáňová, Martina (MBU-M)
Truhlářová, Klára (MBU-M)
Kuzma, Marek (MBU-M) ORCID, RID
Červený, L. (CZ)Zdroj.dok. Reaction Kinetics Mechanism and Catalysis. - : Springer - ISSN 1878-5190
Roč. 124, č. 2 (2018), s. 701-710Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Asymmetric transfer hydrogenation ; Competition ; Dihydroisoquinoline Vědní obor RIV CB - Analytická chemie, separace Obor OECD Analytical chemistry CEP GA15-08992S GA ČR - Grantová agentura ČR LO1509 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora MBU-M - RVO:61388971 UT WOS 000438687600016 EID SCOPUS 85043372376 DOI 10.1007/s11144-018-1387-z Anotace Competitive asymmetric transfer hydrogenation (ATH) of three differently methoxy-substituted 1-methyl-3,4-dihydroisoquinolines (1-Me-DHIQs) was carried out to examine the differences in their reactivity with six ruthenium complexes of the Noyori-Ikariya type having the general formula [Ru(II)Cl(eta(6)-arene)(N-arylsulfonyl-DPEN)] (DPEN = 1,2-diphenylethylene-1,2-diamine). The reaction kinetics of two or three substrates at once was followed in situ by H-1 NMR spectroscopy. A method originally developed for heterogeneous catalysis was used to evaluate the experimental data, providing selectivities of the catalysts to the particular substrates and affinity of these substrates to the active site. The higher reaction rate was usually connected with both higher selectivity and affinity. However, in several cases, the opposite behavior was observed, pointing to a higher selectivity towards the less reactive substrate, which can inhibit the reaction due to its higher affinity. No competitive behavior was manifested in terms of enantioselectivity. As the structure of the Noyori-Ikariya catalytic complexes is highly variable and previous structure-activity studies have often been inconclusive, the presented method may aid in the disentanglement of the complex relationships important for rational catalyst design. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2019
Počet záznamů: 1