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Hybrid .kappa.-carrageenan-based polymers showing “schizophrenic” lower and upper critical solution temperatures and potassium responsiveness
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SYSNO ASEP 0500339 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Hybrid .kappa.-carrageenan-based polymers showing “schizophrenic” lower and upper critical solution temperatures and potassium responsiveness Tvůrce(i) Loukotová, Lenka (UMCH-V) RID, ORCID
Bogomolova, Anna (UMCH-V) RID
Konefal, Rafal (UMCH-V) RID, ORCID
Špírková, Milena (UMCH-V) RID, ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDZdroj.dok. Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 210, 15 April (2019), s. 26-37Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova carrageenan ; polyoxazoline ; LCST Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA18-07983S GA ČR - Grantová agentura ČR LM2015064 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy NV15-25781A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000457707300004 EID SCOPUS 85060186582 DOI 10.1016/j.carbpol.2019.01.050 Anotace Novel multiresponsive hybrid biocompatible systems of kappa-carrageenan-graft-poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)s with unique combination of responsiveness to external stimuli were synthesized and studied. The polymer thermoresponsive behavior proved the existence of both lower and upper critical solution temperatures in aqueous milieu, forming gel at lower temperature, a solution at room temperature and cloudy nanophase-separated dispersion at elevated temperature. The limit temperatures can easily be adjusted by the polyoxazoline graft length and grafting density. Moreover, the polymer behavior is additionally dependent on the concentration of potassium ions. The polymers behave similarly as the original κ-carrageenan, and thus, the poly(2-alkyl-2-oxazoline) grafts do not decrease the ability of the κ-carrageenan to form the self-assembled structures. Molecular principles beyond this multistimuli-responsive behavior were elucidated with the use of dynamic light scattering, magnetic resonance and fluorescence measurements as well as atomic force microscopy. These polymers could be used in a wide range of biological applications demanding thermo- and potassium-responsiveness. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2020 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0144861719300633?via%3Dihub
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