Počet záznamů: 1
The ESC Textbook of Cardiovascular Development
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SYSNO ASEP 0499945 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Developmental aspects of cardiac arrhythmias Tvůrce(i) Postma, A. V. (NL)
Sedmera, David (FGU-C) RID, ORCID, SAI
Vostárek, František (FGU-C) RID, ORCID, SAI
Christoffels, V. M. (NL)
Bezzina, C. R. (NL)Zdroj.dok. The ESC Textbook of Cardiovascular Development. - Oxford : Oxford University Press, 2018 / Pérez-Pomares José M. ; Kelly Robert - ISBN 9780198757269 Rozsah stran s. 269-282 Poč.str. 14 s. Poč.str.knihy 384 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova arrhythmia ; develompent ; heart ; ECG ; transcription factors ; conduction system Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie Obor OECD Cardiac and Cardiovascular systems CEP GAP302/11/1308 GA ČR - Grantová agentura ČR GA13-12412S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 DOI 10.1093/med/9780198757269.003.0027 Anotace The rhythmic and synchronized contraction of atria and ventricles is essential for efficient pumping of blood throughout the body. This process relies on the proper generation and conduction of the cardiac electrical impulse. Electrophysiological properties differ in various regions of the heart, revealing intrinsic heterogeneities rooted, at least in part, in regional differences in expression of ion channel and gap junction subunit genes. A causal relation between transcription factors and such regionalized gene expression has been established. Abnormal cardiac electrical function and arrhythmias in the postnatal heart may stem from a developmental changes in gene regulation. Genome-wide association studies have provided strong evidence that common genetic variation at developmental gene loci modulates electrocardiographic indices of conduction and repolarization and susceptibility to arrhythmia. Functional aspects are illustrated by description of selected prenatally occurring arrhythmias and their possible mechanisms. We also discuss recent findings and provide background insight into these complex mechanisms. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2019
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