Počet záznamů: 1
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
- 1.
SYSNO ASEP 0498725 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations Tvůrce(i) Chang, W.C. (GB)
Kudláček, Jan (FGU-C) ORCID
Hlinka, Jaroslav (UIVT-O) RID, SAI, ORCID
Chvojka, Jan (FGU-C) ORCID
Hadrava, Michal (UIVT-O) RID, ORCID, SAI
Kumpošt, Vojtěch (FGU-C) ORCID
Powell, A. D. (GB)
Janča, R. (CZ)
Maturana, M. I. (AU)
Karoly, P. J. (AU)
Freestone, D. R. (AU)
Cook, M. J. (AU)
Paluš, Milan (UIVT-O) RID, SAI, ORCID
Otáhal, Jakub (FGU-C) RID, ORCID, SAI
Jefferys, J. G. R. (GB)
Jiruška, Přemysl (FGU-C) RID, ORCID, SAIZdroj.dok. Nature Neuroscience. - : Nature Publishing Group - ISSN 1097-6256
Roč. 21, č. 12 (2018), s. 1742-1752Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova seizures ; dynamics ; perturbations ; transition to seizure ; critical slowing ; catastrophic shifts ; high-frequency activity ; interictal epileptiform discharges Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA14-02634S GA ČR - Grantová agentura ČR NV15-29835A GA MZd - Ministerstvo zdravotnictví NV17-28427A GA MZd - Ministerstvo zdravotnictví Institucionální podpora FGU-C - RVO:67985823 ; UIVT-O - RVO:67985807 UT WOS 000451324700012 EID SCOPUS 85057290648 DOI 10.1038/s41593-018-0278-y Anotace The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2019
Počet záznamů: 1