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Roughness of Transmembrane Helices Reduces Lipid Membrane Dynamics
- 1.0497636 - ÚFCH JH 2019 RIV US eng J - Článek v odborném periodiku
Olšinová, Marie - Jurkiewicz, Piotr - Kishko, Irina - Sýkora, Jan - Sabó, Ján - Hof, Martin - Cwiklik, Lukasz - Cebecauer, Marek
Roughness of Transmembrane Helices Reduces Lipid Membrane Dynamics.
iScience. Roč. 10, DEC 2018 (2018), s. 87-97. E-ISSN 2589-0042
Grant CEP: GA ČR GAP305/11/0459; GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA18-26751S
Grant ostatní: GA MŠk(CZ) LM2015042
Institucionální podpora: RVO:61388955
Klíčová slova: LATERAL DIFFUSION * HYDROPHOBIC MISMATCH * PROTEIN INTERACTIONS
Obor OECD: Biophysics
Způsob publikování: Open access
The dynamics of cellular membranes is primarily determined by lipid species forming a bilayer. Proteins are considered mainly as effector molecules of diverse cellular processes. In addition to large assemblies of proteins, which were found to influence properties of fluid membranes, biological membranes are densely populated by small, highly mobile proteins. However, little is known about the effect of such proteins on the dynamics of membranes. Using synthetic peptides, we demonstrate that transmembrane helices interfere with the mobility of membrane components by trapping lipid acyl chains on their rough surfaces. The effect is more pronounced in the presence of cholesterol, which segregates from the rough surface of helical peptides. This may contribute to the formation or stabilization of membrane heterogeneities. Since roughness is a general property of helical transmembrane segments, our results suggest that, independent of their size or cytoskeleton linkage, integral membrane proteins affect local membrane dynamics and organization.
Trvalý link: http://hdl.handle.net/11104/0290177
Název souboru Staženo Velikost Komentář Verze Přístup 0497636.pdf 6 3.5 MB open access Vydavatelský postprint povolen
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