Počet záznamů: 1
Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review
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SYSNO ASEP 0496005 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review Tvůrce(i) Vymetálková, Veronika (UEM-P) RID
Červená, Klára (UEM-P)
Bártů, Linda (UEM-P)
Vodička, Pavel (UEM-P) RIDČíslo článku 3356 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 19, č. 11 (2018)Poč.str. 29 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova cell-free DNA ; colorectal cancer ; liquid biopsy Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP NV17-30920A GA MZd - Ministerstvo zdravotnictví GA18-09709S GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000451528500072 EID SCOPUS 85055655254 DOI 10.3390/ijms19113356 Anotace There is a strong demand for the identification of new biomarkers in colorectal cancer (CRC) diagnosis. Among all liquid biopsy analysts, cell-free circulating DNA (cfDNA) is probably the most promising tool with respect to the identification of minimal residual diseases, assessment of treatment response and prognosis, and identification of resistance mechanisms. Circulating cell-free tumor DNA (ctDNA) maintains the same genomic signatures that are present in the matching tumor tissue allowing for the quantitative and qualitative evaluation of mutation burdens in body fluids. Thus, ctDNA-based research represents a non-invasive method for cancer detection. Among the numerous possible applications, the diagnostic, predictive, and/or prognostic utility of ctDNA in CRC has attracted intense research during the last few years. In the present review, we will describe the different aspects related to cfDNA research and evidence from studies supporting its potential use in CRC diagnoses and the improvement of therapy efficacy. We believe that ctDNA-based research should be considered as key towards the introduction of personalized medicine and patient benefits. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2019
Počet záznamů: 1