Počet záznamů: 1
Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides
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SYSNO ASEP 0495687 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides Tvůrce(i) Pícha, Jan (UOCHB-X) RID, ORCID
Fabre, Benjamin (UOCHB-X) ORCID
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Hajduch, Jan (UOCHB-X) RID
Abdellaoui, Mehdi (UOCHB-X)
Jiráček, Jiří (UOCHB-X) RID, ORCIDZdroj.dok. European Journal of Organic Chemistry - ISSN 1434-193X
Roč. 2018, č. 37 (2018), s. 5180-5192Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova peptide ; solid-phase synthesis ; orthogonal protection Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry CEP GA14-17305S GA ČR - Grantová agentura ČR EF16_019/0000729 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000446662900012 EID SCOPUS 85050621783 DOI 10.1002/ejoc.201800601 Anotace Multi-orthogonal scaffolds can be useful for the attachment of several different compounds to the same central skeleton. Such compounds can find applications in the development of protein mimics because of their potential to mimic several distant epitopes in the protein structure. Three new tri-orthogonal variants of a previously reported scaffold have been developed that are suitable for the solid-phase synthesis of three different peptides on the same skeleton. Different chemical moieties were combined for the phased attachment of amino acids to the scaffolds: Fmoc- or Alloc-protected amine, free or TIPS-protected alkyne or azido group. Several model compounds were prepared, characterized, and compared for their suitability as new scaffolds for peptide synthesis. All three scaffolds provided peptides with satisfactory yields and purities, making them suitable for a synthesis of libraries of compounds. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2019
Počet záznamů: 1