Počet záznamů: 1
Isomeric Naphtho-Fused 7-Deazapurine Nucleosides and Nucleotides: Synthesis, Biological Activity, Photophysical Properties and Enzymatic Incorporation to Nucleic Acids
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SYSNO ASEP 0495509 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Isomeric Naphtho-Fused 7-Deazapurine Nucleosides and Nucleotides: Synthesis, Biological Activity, Photophysical Properties and Enzymatic Incorporation to Nucleic Acids Tvůrce(i) Ghosh, Ketaki (UOCHB-X)
Perlíková, Pavla (UOCHB-X) RID, ORCID
Havlíček, Vojtěch (UOCHB-X)
Yang, Chao (UOCHB-X) ORCID
Pohl, Radek (UOCHB-X) RID, ORCID
Tloušťová, Eva (UOCHB-X) RID, ORCID
Hodek, Jan (UOCHB-X) RID, ORCID
Gurská, S. (CZ)
Džubák, P. (CZ)
Hajdúch, M. (CZ)
Hocek, Michal (UOCHB-X) RID, ORCIDZdroj.dok. European Journal of Organic Chemistry - ISSN 1434-193X
Roč. 2018, č. 37 (2018), s. 5092-5108Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova nucleosides ; nucleotides ; fused heterocycles ; cytostatics ; antiviral agents Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry CEP GA16-00178S GA ČR - Grantová agentura ČR TE01020028 GA TA ČR - Technologická agentura ČR LO1304 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2015064 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000446662900004 EID SCOPUS 85046750074 DOI 10.1002/ejoc.201800165 Anotace Two series of substituted benzo[g]- or benzo[e]pyrimido[4,5-b]indole (naphtho-fused 7-deazapurine) ribonucleosides were synthesized. The heterocyclic nucleobases were obtained by Negishi cross-coupling reaction of zincated pyrimidines with naphthyl iodides, nucleophilic substitution to tetrazoles/azides and thermal cyclization or photocyclization. Nucleosides were obtained by glycosylation followed by substitution reactions and deprotection. Resulting ribonucleosides were tested for their cytotoxic activity against cancer cell lines and antiviral activities. Some derivatives showed micromolar cytotoxic activities and moderate anti-hepatitis C virus activities. Naphtho-fused 7-deazapurine 2-deoxyribonucleoside triphosphate was successfully incorporated into DNA oligonucleotides by KOD XL DNA polymerase. Fluorescence properties of naphtho-fused 7-deazapurine nucleosides and oligonucleotides were also studied. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2019
Počet záznamů: 1