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Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status
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SYSNO ASEP 0489791 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status Tvůrce(i) Rauchová, Hana (FGU-C) RID, ORCID
Vokurková, Martina (FGU-C) RID
Pavelka, Stanislav (FGU-C) RID
Vaněčková, Ivana (FGU-C) RID, ORCID
Tribulová, N. (SK)
Soukup, Tomáš (FGU-C) RIDZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 67, č. 2 (2018), s. 307-315Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova hypothyroidism ; hyperthyroidism ; heart ; cholesterol ; glutathione Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP NV15-25396A GA MZd - Ministerstvo zdravotnictví Institucionální podpora FGU-C - RVO:67985823 UT WOS 000431452400016 EID SCOPUS 85046831078 DOI 10.33549/physiolres.933834 Anotace Red palm oil (RPO) is a rich natural source of antioxidant vitamins, namely carotenes, tocopherols and tocotrienols. However, it contains approximately 50 % saturated fatty acids the regular consumption of which could negatively modify lipid profile. The aim of our study was to test whether 7 weeks of RPO supplementation (1 g/kg body weight/day) would affect blood glucose and lipid metabolism in adult male Wistar rats with altered thyroid status. We induced hypothyroidism and hyperthyroidism in rats by oral administration of either methimazole or mixture of thyroid hormones. Different thyroid status (EU - euthyroid, HY - hypothyroid and HT - hyperthyroid) was characterized by different serum thyroid hormones levels (total and free thyroxine and triiodothyronine), changes in the activity of a marker enzyme of thyroid status - liver mitochondrial glycerol-3-phosphate dehydrogenase, and altered absolute and relative heart weights. Fasting blood glucose levels were higher in HT rats in comparison with EU and HY rats, but the changes caused by RPO supplementation were not significant. The achievement of the HY status significantly increased serum levels of total cholesterol, as well as with high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol: 2.43 +/- 0.15, 1.48 +/- 0.09, 0.89 +/- 0.08 mmol/l, compared to EU: 1.14 +/- 0.06, 0.77 +/- 0.06, 0.34 +/- 0.05 mmol/l and HT: 1.01 +/- 0.06, 0.69 +/- 0.04, 0.20 +/- 0.03 mmol/l, respectively. RPO supplementation did not increase significantly levels of blood lipids but tended to increase glutathione levels in the liver. In conclusion, RPO supplementation did not induce the presumed deterioration of glucose and lipid metabolism in rats with three well-characterized alterations in thyroid status. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2019
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