Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.

Szczurowska, E.; Ahuja, Nikhil; Jiruška, Přemysl; Kelemen, E.; Stuchlík, Aleš

doi:https://dx.doi.org/10.1016/j.pnpbp.2017.09.013

Počet záznamů: 1

Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.

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SYSNO ASEP	0489341
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.
Tvůrce(i)	Szczurowska, E. (CZ) Ahuja, Nikhil (FGU-C)_{RID, ORCID, SAI} Jiruška, Přemysl (FGU-C)_{RID, ORCID, SAI} Kelemen, E. (CZ) Stuchlík, Aleš (FGU-C)_{RID, ORCID}
Zdroj.dok.	Progress in Neuro-Psychopharmacology & Biological Psychiatry. - : Elsevier - ISSN 0278-5846 Roč. 81, Feb 2 (2018), s. 275-283
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	psychosis ; MK-801 ; neuronal discoordination ; hippocampus ; Theta rhythm
Vědní obor RIV	FH - Neurologie, neurochirurgie, neurovědy
Obor OECD	Neurosciences (including psychophysiology
CEP	GA17-04047S GA ČR - Grantová agentura ČR
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000414901100032
EID SCOPUS	85029675626
DOI	10.1016/j.pnpbp.2017.09.013
Anotace	The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including 'hallmark' cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15 mg/kg dizocilpine (MK-801), an N-Methyl-D-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2019

Počet záznamů: 1