Počet záznamů: 1
Long and small noncoding RNAs during oocyte-to-embryo transition in mammals
- 1.0487078 - ÚMG 2018 RIV GB eng J - Článek v odborném periodiku
Svoboda, Petr
Long and small noncoding RNAs during oocyte-to-embryo transition in mammals.
Biochemical Society Transactions. Roč. 45, říjen (2017), s. 1117-1124. ISSN 0300-5127. E-ISSN 1470-8752
Grant CEP: GA MŠMT LO1419
Institucionální podpora: RVO:68378050
Klíčová slova: inactive x-chromosome * stem-cells * endogenous sirnas * gene-expression * xist expression * mouse oocytes * preimplantation development * molecular-mechanisms * somatic-cells * evolution
Obor OECD: Reproductive biology (medical aspects to be 3)
Impakt faktor: 3.394, rok: 2017
Oocyte-to-embryo transition is a process during which an oocyte ovulates, is fertilized, and becomes a developing embryo. It involves the first major genome reprogramming event in life of an organism where gene expression, which gave rise to a differentiated oocyte, is remodeled in order to establish totipotency in blastomeres of an early embryo. This remodeling involves replacement of maternal RNAs with zygotic RNAs through maternal RNA degradation and zygotic genome activation. This review is focused on expression and function of long noncoding RNAs (lncRNAs) and small RNAs during oocyte-to-embryo transition in mammals. LncRNAs are an assorted rapidly evolving collection of RNAs, which have no apparent protein-coding capacity. Their biogenesis is similar to mRNAs including transcriptional control and post-transcriptional processing. Diverse molecular and biological roles were assigned to lncRNAs although most of them probably did not acquire a detectable biological role. Since some lncRNAs serve as precursors for small noncoding regulatory RNAs in RNA silencing pathways, both types of noncoding RNA are reviewed together.
Trvalý link: http://hdl.handle.net/11104/0281760
Počet záznamů: 1