Počet záznamů: 1
Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis
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SYSNO ASEP 0484778 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis Tvůrce(i) Kalousová, M. (CZ)
Dusilová-Sulková, S. (CZ)
Kuběna, A.A. (CZ)
Zakiyanov, O. (CZ)
Levová, K. (CZ)
Bocková, Markéta (URE-Y)
Gedeonová, Erika (URE-Y)
Chadtová Song, Xue (URE-Y)
Ermini, Maria Laura (URE-Y)
Špringer, Tomáš (URE-Y)
Homola, Jiří (URE-Y) RID
Tesař, V. (CZ)
Zima, T. (CZ)Celkový počet autorů 13 Zdroj.dok. Kidney & Blood Pressure Research. - : Karger - ISSN 1420-4096
Roč. 42, č. 3 (2017), s. 509-518Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Surface plasmon resonance ; Hemodialysis ; Infection ; Mortality Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GBP205/12/G118 GA ČR - Grantová agentura ČR Institucionální podpora URE-Y - RVO:67985882 UT WOS 000414970500011 EID SCOPUS 85028768496 DOI 10.1159/000479847 Anotace Background: Pregnancy-associated plasma protein A (PAPP-A) is associated with adverse outcome of long-term hemodialysis patients (HD). The aim of the study was to test whether its homolog pregnancy-associated plasma protein A2 (PAPP-A2) can be detected in serum of HD patients and to define its significance. Methods: The studied group consisted of 102 long-term HD patients and 25 healthy controls. HD patients were prospectively followed up for five years (2009-2014). PAPP-A2 was measured by surface plasmon resonance biosensor, PAPP-A by time resolved amplified cryptate emission. Results: PAPP-A2, similarly as PAPP-A, was significantly increased in HD patients (median (interquartile range)) PAPP-A2: 6.2 (2.6-10.8) ng/mL, vs. 3.0 (0.7-5.9) ng/mL, p=0.006, PAPP-A: 18.9 (14.3-23.4) mIU/L, vs. 9.5 (8.4-10.5) mIU/L, p < 0.001). In HD patients, PAPP-A2 correlated weakly but significantly with PAPP-A (tau=0.193, p=0.004). Unlike PAPP-A, PAPP-A2 was not significant for prognosis of HD patients when tested alone. There was a significant interaction between PAPP-A and PAPP-A2 on the mortality due to infection of HD patients (p=0.008). If PAPP-A was below median, mortality due to infection was significantly higher for patients with PAPP-A2 values above median than for patients with low PAPP-A2 levels (p=0.011). Conclusion: PAPP-A2 is increased in HD patients and interacts with PAPP-A on patients´prognosis Pracoviště Ústav fotoniky a elektroniky Kontakt Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Rok sběru 2018
Počet záznamů: 1