Počet záznamů: 1
Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases
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SYSNO ASEP 0483977 Druh ASEP B - Monografie Zařazení RIV B - Odborná monografie, kniha Název Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases Tvůrce(i) Ježek, Jan (UOCHB-X) RID
Hlaváček, Jan (UOCHB-X)
Šebestík, Jaroslav (UOCHB-X) RID, ORCIDVyd. údaje Cham: Springer, 2017 ISBN 978-3-319-63952-9 ISSN 0071-786X Edice Progress in Drug Research Č. sv. edice 72 Poč.str. 237 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova acridine ; acridine-protein interactions ; acridine-nucleic acid interactions ; neurodegenerative diseases Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry CEP GA14-00431S GA ČR - Grantová agentura ČR GA17-00121S GA ČR - Grantová agentura ČR Institucionální podpora UOCHB-X - RVO:61388963 DOI 10.1007/978-3-319-63953-6 Anotace This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis,
comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2018
Počet záznamů: 1