Počet záznamů: 1
Intercellular crosstalk in human malignant melanoma
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SYSNO ASEP 0477963 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Intercellular crosstalk in human malignant melanoma Tvůrce(i) Dvořánková, Barbora (UMG-J)
Szabo, Pavol (UMG-J)
Kodet, O. (CZ)
Strnad, Hynek (UMG-J) RID
Kolář, Michal (UMG-J) RID, ORCID
Lacina, L. (CZ)
Krejčí, E. (CZ)
Nanka, O. (CZ)
Sedo, A. (CZ)
Smetana, K. (CZ)Celkový počet autorů 10 Zdroj.dok. Protoplasma - ISSN 0033-183X
Roč. 254, č. 3 (2017), s. 1143-1150Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. AT - Rakousko Klíč. slova Melanocyte ; Melanoma cells ; Melanoma ecosystem ; cancer-associated fibroblast ; Keratinocyte ; Cytokine Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP GA16-05534S GA ČR - Grantová agentura ČR LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMG-J - RVO:68378050 UT WOS 000399037400002 DOI 10.1007/s00709-016-1038-z Anotace Incidence of malignant melanoma is increasing globally. While the initial stages of tumors can be easily treated by a simple surgery, the therapy of advanced stages is rather limited. Melanoma cells spread rapidly through the body of a patient to form multiple metastases. Consequently, the survival rate is poor. Therefore, emphasis in melanoma research is given on early diagnosis and development of novel and more potent therapeutic options. The malignant melanoma is arising from melanocytes, cells protecting mitotically active keratinocytes against damage caused by UV light irradiation. The melanocytes originate in the neural crest and consequently migrate to the epidermis. The relationship between the melanoma cells, the melanocytes, and neural crest stem cells manifests when the melanoma cells are implanted to an early embryo: they use similar migratory routes as the normal neural crest cells. Moreover, malignant potential of these melanoma cells is overdriven in this experimental model, probably due to microenvironmental reprogramming. This observation demonstrates the crucial role of the microenvironment in melanoma biology. Indeed, malignant tumors in general represent complex ecosystems, where multiple cell types influence the growth of genetically mutated cancer cells. This concept is directly applicable to the malignant melanoma. Our review article focuses on possible strategies to modify the intercellular crosstalk in melanoma that can be employed for therapeutic purposes. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2018
Počet záznamů: 1