Počet záznamů: 1
Myocardial ischemic tolerance in rats subjected to endurance exercise training during adaptation to chronic hypoxia
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SYSNO ASEP 0475735 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Myocardial ischemic tolerance in rats subjected to endurance exercise training during adaptation to chronic hypoxia Tvůrce(i) Alánová, Petra (FGU-C) RID, ORCID
Chytilová, Anna (FGU-C)
Neckář, Jan (FGU-C) RID, ORCID
Hrdlička, Jaroslav (FGU-C) ORCID, RID
Míčová, P. (CZ)
Holzerová, Kristýna (FGU-C) ORCID, RID
Hlaváčková, Markéta (FGU-C) RID, ORCID
Macháčková, Kristýna (FGU-C)
Papoušek, František (FGU-C)
Vašinová, Jana (FGU-C)
Benák, Daniel (FGU-C)
Nováková, Olga (FGU-C)
Kolář, František (FGU-C) RID, ORCID, SAIZdroj.dok. Journal of Applied Physiology. - : American Physiological Society - ISSN 8750-7587
Roč. 122, č. 6 (2017), s. 1452-1461Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova chronic hypoxia ; exercise training ; cardioprotection ; cytokines ; antioxidants Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie Obor OECD Physiology (including cytology) CEP GA13-10267S GA ČR - Grantová agentura ČR GJ16-12420Y GA ČR - Grantová agentura ČR GAP303/12/1162 GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000404377000010 EID SCOPUS 85021058492 DOI 10.1152/japplphysiol.00671.2016 Anotace Chronic hypoxia and exercise are natural stimuli that confer sustainable cardioprotection against ischemia-reperfusion (I/R) injury, but it is unknown whether they can act in synergy to enhance ischemic resistance. Inflammatory response mediated by tumor necrosis factor-alpha (TNF-alpha) plays a role in the infarct size limitation by continuous normobaric hypoxia (CNH), whereas exercise is associated with anti-inflammatory effects. This study was conducted to determine if exercise training performed under conditions of CNH (12% O2) affects myocardial ischemic resistance with respect to inflammatory and redox status. Adult male Wistar rats were assigned to one of the following groups: normoxic sedentary, normoxic trained, hypoxic sedentary, and hypoxic trained. CNH increased TNF-alpha and interleukin-6 levels and the expression of TNF-alpha type 2 receptor, nuclear factor-kappaB (NF-kappaB), inducible nitric oxide synthase (iNOS), cytosolic phospholipase A2, cyclooxygenase-2, manganese superoxide dismutase (MnSOD), and catalase. None of these effects occurred in the normoxic trained group, whereas exercise in hypoxia abolished or significantly attenuated CNH-induced responses, except for NF-kappaB, iNOS, and MnSOD. Both CNH and exercise reduced infarct size, but their combination provided the same degree of protection as CNH alone. In conclusion, exercise training does not amplify the cardioprotection conferred by CNH. High ischemic tolerance of the CNH hearts persists after exercise, possibly by maintaining the increased antioxidant capacity despite attenuating TNF-alpha-dependent protective signaling. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2018
Počet záznamů: 1