Počet záznamů: 1
Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1
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SYSNO ASEP 0472521 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1 Tvůrce(i) Deloizy, Ch. (FR)
Bouguyon, E. (FR)
Fossum, E. (NO)
Šebo, Peter (MBU-M) RID, ORCID
Osička, Radim (MBU-M) RID, ORCID
Bole, A. (FR)
Pierres, M. (FR)
Biacchesi, S. (FR)
Dalod, M. (FR)
Bogen, B. (NO)
Bertho, N. (FR)
Schwartz-Cornil, I. (FR)Zdroj.dok. Developmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X
Roč. 65, December 2016 (2016), s. 31-40Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Mononuclear phagocytes ; Dendritic cells ; Pig model Vědní obor RIV EE - Mikrobiologie, virologie CEP GA15-09157S GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000384388400004 EID SCOPUS 84977134494& DOI 10.1016/j.dci.2016.06.015 Anotace ig is a domestic species of major importance in the agro-economy and in biomedical research. Mononuclear phagocytes (MNP) are organized in subsets with specialized roles in the orchestration of the immune response and new tools are awaited to improve MNP subset identification in the pig. We cloned pig CD11c cDNA and generated a monoclonal antibody to pig CD11c which showed a pattern of expression by blood and skin MNP subsets similar to humans. We also developed a porcine XCL1-mCherry dimer which specifically reacted with the XCR1-expressing dendritic cell subset of the type 1 lineage in blood and skin. These original reagents will allow the efficient identification of pig MNP subsets to study their role in physiological and pathological processes and also to target these cells in novel intervention and vaccine strategies for veterinary applications and preclinical evaluations. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2017
Počet záznamů: 1