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Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties
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SYSNO ASEP 0462569 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties Tvůrce(i) Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Březinová, Marie (FGU-C) ORCID
Rombaldová, Martina (FGU-C) RID, ORCID
Slavíková, Barbora (UOCHB-X) RID, ORCID
Pošta, Martin (UOCHB-X) RID
Beier, Petr (UOCHB-X) RID, ORCID
Janovská, Petra (FGU-C) RID, ORCID
Veleba, J. (CZ)
Kopecký Jr., J. (CZ)
Kudová, Eva (UOCHB-X) RID, ORCID
Pelikánová, T. (CZ)
Kopecký, Jan (FGU-C) RID, ORCIDZdroj.dok. Diabetes. - : American Diabetes Association - ISSN 0012-1797
Roč. 65, č. 9 (2016), s. 2580-2590Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova FAHFA ; n-3 PUFA ; white adipose tissue ; lipokine Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa CEP LH14040 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GB14-36804G GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 ; UOCHB-X - RVO:61388963 UT WOS 000382099800014 EID SCOPUS 84983523949 DOI 10.2337/db16-0385 Anotace White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obese individuals, contributes to the development of insulin resistance and type 2 diabetes. n-3 polyunsaturated fatty acids (PUFAs) of marine origin play an important role in the resolution of inflammation and exert beneficial metabolic effects. Using experiments in mice and overweight/obese patients with type 2 diabetes, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids—lipokines derived from docosahexaenoic acid (DHA) and linoleic acid, which were present in serum and WAT after n-3 PUFA supplementation. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) or 14-hydroxydocosahexaenoic acid (HDHA), termed 9-DHAHLA, 13-DHAHLA, and 14-DHAHDHA, and were synthesized by adipocytes at concentrations comparable to those of protectins and resolvins derived from DHA in WAT. 13-DHAHLA exerted anti-inflammatory and proresolving properties while reducing macrophage activation by lipopolysaccharides and enhancing the phagocytosis of zymosan particles. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed to n-3 PUFAs, in both mice and humans. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2017
Počet záznamů: 1