Počet záznamů: 1
cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes
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SYSNO ASEP 0462060 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes Tvůrce(i) Ahmad, Jawid Nazir (MBU-M) RID
Černý, Ondřej (MBU-M)
Linhartová, Irena (MBU-M) RID, ORCID
Mašín, Jiří (MBU-M) RID, ORCID
Osička, Radim (MBU-M) RID, ORCID
Šebo, Peter (MBU-M) RID, ORCIDZdroj.dok. Cellular Microbiology. - : Wiley - ISSN 1462-5814
Roč. 18, č. 3 (2016), s. 384-398Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova FORKHEAD TRANSCRIPTION FACTOR ; HUMAN T-CELLS ; DENDRITIC CELLS Vědní obor RIV EE - Mikrobiologie, virologie CEP GA13-14547S GA ČR - Grantová agentura ČR GAP302/11/0580 GA ČR - Grantová agentura ČR GAP302/12/0460 GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000370643500007 EID SCOPUS 84958102950 DOI 10.1111/cmi.12519 Anotace The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) plays a key role in virulence of Bordetella pertussis. CyaA penetrates myeloid cells expressing the complement receptor 3 ((M2) integrin CD11b/CD18) and subverts bactericidal capacities of neutrophils and macrophages by catalysing unregulated conversion of cytosolic ATP to the key signalling molecule adenosine 3',5'-cyclic monophosphate (cAMP). We show that the signalling of CyaA-produced cAMP hijacks, by an as yet unknown mechanism, the activity of the tyrosine phosphatase SHP-1 and activates the pro-apoptotic BimEL-Bax cascade. Mitochondrial hyperpolarization occurred in human THP-1 macrophages within 10min of exposure to low CyaA concentrations (e.g. 20ngml(-1)) and was accompanied by accumulation of BimEL and association of the pro-apoptotic factor Bax with mitochondria. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2017
Počet záznamů: 1