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Muscarinic Receptor: From Structure to Animal Models
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SYSNO ASEP 0458556 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release Tvůrce(i) Alquicer, Glenda (FGU-C) ORCID
Doležal, Vladimír (FGU-C) RID, ORCID
El-Fakahany, E. E. (US)Zdroj.dok. Muscarinic Receptor: From Structure to Animal Models. - New York : Springer, 2016 / Mysliveček Jaromír ; Jakubík Jan - ISSN 0893-2336 - ISBN 978-1-4939-2857-6 Rozsah stran s. 221-233 Poč.str. 13 s. Poč.str.knihy 287 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova muscarinic receptors ; acetylcholine release ; autoregulation ; superfusion Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP GA14-05696S GA ČR - Grantová agentura ČR EE2.3.30.0025 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 UT WOS 000366481100014 EID SCOPUS 84938703252 DOI 10.1007/978-1-4939-2858-3_12 Anotace Signal transmission from cholinergic nerves is mediated by two receptor families: ionotropic nicotinic and metabotropic (G-protein coupled) muscarinic receptors. The muscarinic receptor family comprises five receptor subtypes (M1 through M5), each encoded by its own gene. Individual subtypes play important specific roles in many physiological processes, ranging from vegetative to cognitive functions and memory. Cloning of individual muscarinic receptor subtypes has enabled targeted studies of ligand binding and activation characteristics of the recombinant protein and a rapid increase in the development of receptor selective drugs for various potential therapeutic uses. Results of testing new drugs obtained on recombinant proteins need to be verified using systems that better mimic a physiological environment. Here we provide a brief outline and examples of the utilization of superfused brain slices for probing drug effects on muscarinic autoreceptor-mediated regulation of acetylcholine release. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2017
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