Počet záznamů: 1
Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses
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SYSNO ASEP 0456291 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses Tvůrce(i) Ambrožová, Gabriela (BFU-R) RID
Martíšková, Hana (BFU-R) ORCID
Koudelka, A. (CZ)
Ravekes, T. (DE)
Rudolph, T.K. (DE)
Klinke, A. (DE)
Rudolph, V. (DE)
Freeman, B.A. (US)
Woodcock, S.R. (US)
Kubala, Lukáš (BFU-R) RID, ORCID
Pekarová, Michaela (BFU-R) RIDCelkový počet autorů 11 Zdroj.dok. Free Radical Biology and Medicine. - : Elsevier - ISSN 0891-5849
Roč. 90, JAN 2016 (2016), s. 252-260Poč.str. 9 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Nitro-fatty acids ; Nitro-oleic acid ; Macrophages Vědní obor RIV BO - Biofyzika CEP GP13-40824P GA ČR - Grantová agentura ČR Institucionální podpora BFU-R - RVO:68081707 UT WOS 000367396600023 DOI 10.1016/j.freeradbiomed.2015.11.026 Anotace Inflammation is an immune response triggered by microbial invasion and/or tissue injury. While acute inflammation is directed toward invading pathogens and injured cells, thus enabling tissue regeneration, chronic inflammation can lead to severe pathologies and tissue dysfunction. These processes are linked with macrophage polarization into specific inflammatory "M1-like" or regulatory "M2-like" subsets. Nitro-fatty acids (NO2-FAs), produced endogenously as byproducts of metabolism and oxidative inflammatory conditions, may be useful for treating diseases associated with dysregulated immune homeostasis. The goal of this study was to characterize the role of nitro-oleic acid (OA-NO2) in regulating the functional specialization of macrophages induced by bacterial lipopolysaccharide or interleukin-4, and to reveal specific signaling mechanisms which can account for OA-NO2-dependent modulation of inflammation and fibrotic responses. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2016
Počet záznamů: 1