Počet záznamů: 1
Organization of the expanded cumulus-extracellular matrix in preovulatory follicles: arole for inter-alpha-trypsin inhibitor.
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SYSNO ASEP 0451700 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve SCOPUS Název Organization of the expanded cumulus-extracellular matrix in preovulatory follicles: arole for inter-alpha-trypsin inhibitor. Tvůrce(i) Nagyová, Eva (UZFG-Y) RID, ORCID Zdroj.dok. Endocrine Regulations. - : AEPress - ISSN 1210-0668
Roč. 49, č. 1 (2015), s. 37-45Poč.str. 9 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. SK - Slovensko Klíč. slova cumulus expansion ; cumulus-extracellular matrix ; hyaluronan Vědní obor RIV ED - Fyziologie CEP GA305/05/0960 GA ČR - Grantová agentura ČR Institucionální podpora UZFG-Y - RVO:67985904 EID SCOPUS 84944177352 Anotace It has been shown that following endogenous gonadotropin surge, oocyte-cumulus complexes (OCC) synthesize hyaluronan (HA) in a process called cumulus expansion. During this process, HA associates with proteins and proteoglycans to form the expanded HA-rich oocyte-cumulus extracellular matrix (ECM), where the heavy chains of the serum derived inter-alpha-trypsin inhibitor family (IalphaI) bind covalently to HA. No study has been performed on the occurrence and regulation of this process during oocyte maturation in species other than mouse and pig, although, the heavy chains (of IalphaI)-HA complex was purified from human amniotic membrane. The present review pointing out that: 1/ formation of expanded HA-rich oocyte-cumulus ECM is dependent on the presence of IalphaI molecules, 2/ the heavy chains of IalphaI molecules identified in the serum are covalently linked to HA during cumulus expansion in mouse and pig, 3/ the family of IalphaI molecules can freely cross the blood-follicle barrier, and the follicular fluid collected at any stage of folliculogenesis can be successfully used instead of serum to form expanded cumulus ECM in pig, and 4/ proteins of the IalphaI family can affect reproductive process by modulating the expression of a large number of cellular genes during a preovulatory period. Finally, this review provides clear evidence that IalphaI family members present in the serum or follicular fluid become responsible for cumulus expansion, as without these proteins, expanded cumulus HA-rich ECM is not formed and HA is released into medium. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2016
Počet záznamů: 1