Počet záznamů: 1
Mitochondrial dysfunction and disturbed coherence: Gate to cancer
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SYSNO ASEP 0449548 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve SCOPUS Název Mitochondrial dysfunction and disturbed coherence: Gate to cancer Tvůrce(i) Pokorný, Jiří (URE-Y) RID
Pokorný, Jan (FZU-D) RID, ORCID
Foletti, A. (CH)
Kobilková, J. (CZ)
Vrba, J. (CZ)
Vrba, J. jr. (CZ)Celkový počet autorů 6 Zdroj.dok. Pharmaceuticals. - : MDPI
Roč. 8, č. 4 (2015), s. 675-695Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova LDH virus ; Mitochondrial dysfunction ; Cancer biophysics Vědní obor RIV JA - Elektronika a optoelektronika, elektrotechnika Vědní obor RIV – spolupráce Fyzikální ústav - Fyzika pevných látek a magnetismus Institucionální podpora URE-Y - RVO:67985882 ; FZU-D - RVO:68378271 EID SCOPUS 84943184091 DOI 10.3390/ph8040675 Anotace Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruvate transfer to the mitochondrial matrix, either by parasitic consumption and/or mitochondrial dysfunction. This can in turn lead to disturbance in water molecules’ ordering, diminished power, and coherence of the electromagnetic field. In tumors with the Warburg (reverse Warburg) effect, mitochondrial dysfunction affects cancer cells (fibroblasts associated with cancer cells), and the electromagnetic field generated by microtubules in cancer cells has low power (high power due to transport of energy-rich metabolites from fibroblasts), disturbed coherence, and a shifted frequency spectrum according to changed power. Therapeutic strategies restoring mitochondrial function may trigger apoptosis in treated cells; yet, before this step is performed, induction (inhibition) of pyruvate dehydrogenase kinases (phosphatases) may restore the cancer state. In tumor tissues with the reverse Warburg effect, Caveolin-1 levels should be restored and the transport of energy-rich metabolites interrupted to cancer cells. In both cancer phenotypes, achieving permanently reversed mitochondrial dysfunction with metabolic-modulating drugs may be an effective, specific anti-cancer strategy Pracoviště Ústav fotoniky a elektroniky Kontakt Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Rok sběru 2016
Počet záznamů: 1