Počet záznamů: 1
N-(2-hydroxypropyl) methacrylamide based cryogels - synthesis and biomimetic modification for stem cell applications
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SYSNO ASEP 0448561 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název N-(2-hydroxypropyl) methacrylamide based cryogels - synthesis and biomimetic modification for stem cell applications Tvůrce(i) Golunova, Anna (UMCH-V) RID, ORCID
Jaroš, J. (CZ)
Jurtíková, V. (CZ)
Kotelnikov, Ilya (UMCH-V) RID, ORCID
Kotek, Jiří (UMCH-V) RID
Hlídková, Helena (UMCH-V) RID, ORCID
Streit, L. (CZ)
Hampl, A. (CZ)
Rypáček, František (UMCH-V) RID
Proks, Vladimír (UMCH-V) RID, ORCIDZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 64, Suppl. 1 (2015), S19-S27Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova hydrogels ; cryogels ; stem cells Vědní obor RIV EB - Genetika a molekulární biologie CEP GA13-29009S GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000365010700004 EID SCOPUS 84952651192 Anotace The design of favorable mechanical properties and suitable surface modifications of hydrogels in order to stimulate specific cell response is a great challenge. N-(2-Hydroxypropyl) methacryl-amide (HPMA) was utilized to form macroporous cryogel scaffolds for stem cell applications. Furthermore, one group of scaffolds was enhanced by copolymerization of HPMA with methacryloyl-GGGRGDS-OH peptide in an effort to integrate biomimetic adhesion sites. The cryogels were characterized by stiffness and equilibrium swelling measurements as well as by scanning electron microscopy. Cell culture experiments were performed with human adipose-derived stem cells and substrates were found completely non-toxic. Moreover, RGDS-enriched cryogels supported cell attachment, spreading and proliferation, so they can be considered suitable for designed aims. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2016 Elektronická adresa http://www.biomed.cas.cz/physiolres/pdf/64%20Suppl%201/64_S19.pdf
Počet záznamů: 1