Novel nanocrystalline diamond coating of coronary stents reduces neointimal hyperplasia in pig model

0440840 - FZÚ 2015 RIV CA eng J - Článek v odborném periodiku
Kočka, V. - Jirásek, T. - Taylor, Andrew - Fendrych, František - Rezek, Bohuslav - Šimůnková, Z. - Mrázová, I. - Toušek, P. - Mistrík, J. - Mandys, V. - Nesládek, M.
Novel nanocrystalline diamond coating of coronary stents reduces neointimal hyperplasia in pig model.
Experimental and Clinical Cardiology. Roč. 20, č. 1 (2014), s. 65-76. ISSN 1205-6626
Grant CEP: GA AV ČR KAN200100801
Institucionální podpora: RVO:68378271
Klíčová slova: stents * nanotechnology * restenosis * optical coherence tomography * diamond
Kód oboru RIV: BM - Fyzika pevných látek a magnetismus
Impakt faktor: 0.758, rok: 2013

Objectives: This study sought to study the performance of nanocrystalline diamond (NCD) coated stainless steel (SS) coronary stent in a pig coronary artery model. Background: Diamond is hard, biocompatible material which offers the possibility of functionalization by covalent carbon chemistry. Results: All animals survived and all stents were patent at 6 weeks. There was a significantly larger lumen area in the NCD group (4.8±0.97 versus 3.85±0.87 mm2, p=0.02). The neointimal hyperplasia area was smaller in the NCD group by 37% (1.57±0.63 mm2 in NCD group versus 2.39±0.87 mm2 in SS group, p=0.02). There was no difference in stent strut apposition and coverage between NCD and SS group.
Trvalý link: http://hdl.handle.net/11104/0243938