Počet záznamů: 1
Changes in FGF21 Serum Concentrations and Liver mRNA Expression in an Experimental Model of Complete Lipodystrophy and Insulin-Resistant Diabetes
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SYSNO ASEP 0434081 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Changes in FGF21 Serum Concentrations and Liver mRNA Expression in an Experimental Model of Complete Lipodystrophy and Insulin-Resistant Diabetes Tvůrce(i) Špolcová, Andrea (UOCHB-X) RID, ORCID
Holubová, Martina (UOCHB-X) RID, ORCID
Mikulášková, Barbora (UOCHB-X)
Nagelová, Veronika (UOCHB-X) RID, ORCID
Štofková, A. (CZ)
Lacinová, Z. (CZ)
Jurčovičová, J. (CZ)
Haluzík, M. (CZ)
Maletínská, Lenka (UOCHB-X) RID, ORCID
Železná, Blanka (UOCHB-X) RID, ORCIDCelkový počet autorů 10 Zdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 63, č. 4 (2014), s. 483-490Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova FGF21 ; A-ZIP mice ; lipodystrophy ; insulin resistance ; fatty liver ; GLUT-1 Vědní obor RIV CE - Biochemie CEP GAP303/10/1368 GA ČR - Grantová agentura ČR GAP303/12/0576 GA ČR - Grantová agentura ČR Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000342568400009 EID SCOPUS 84910053633 Anotace Patients with obesity and type 2 diabetes often display high levels of the anti-diabetic factor fibroblast growth factor-21 (FGF21), suggesting that the overproduction of FGF21 may result from increased adiposity in an attempt by white adipose tissue (WAT) to counteract insulin resistance. However, the production of FGF21 diabetes in the absence of WAT has not been examined. In this study, we investigated the effects of lipodystrophy in A-ZIP F-1 mice on FGF21 production in relation to diabetes. A-ZIP F-1 mice displayed high FGF21 plasma levels resulting from enhanced FGF21 mRNA expression in the liver. Concomitant enhancement of FGF21 receptor (FGFR1) and glucose transporter 1 (GLUT-1) mRNA expression was observed in the muscles of A-ZIP F-1 mice. Furthermore, the activation of hypothalamic NPY and AgRP mRNA expression positively correlated with plasma levels of FGF21 but not active ghrelin. Our study demonstrates that an increased FGF21 plasma level in lipodystrophic A-ZIP F-1 mice results mainly from up-regulated liver production but does not suffice to overcome the lipodystrophy-induced severe type 2-diabetes and insulin resistance in the liver linked to the augmented liver fat deposition. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2015
Počet záznamů: 1