Počet záznamů: 1
Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats
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SYSNO ASEP 0433963 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats Tvůrce(i) Špolcová, Andrea (UOCHB-X) RID, ORCID
Mikulášková, Barbora (UOCHB-X)
Kršková, K. (SK)
Gajdošechová, L. (SK)
Zórad, Š. (SK)
Olszanecki, R. (PL)
Suski, M. (PL)
Bujak-Gizycka, B. (PL)
Železná, Blanka (UOCHB-X) RID, ORCID
Maletínská, Lenka (UOCHB-X) RID, ORCIDCelkový počet autorů 10 Zdroj.dok. BMC Neuroscience. - : BioMed Central - ISSN 1471-2202
Roč. 15, Sep 25 (2014), 111/1-111/8Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Zucker fa/fa rats ; insulin resistance ; obesity ; GSK-3 beta ; Tau protein Vědní obor RIV CE - Biochemie CEP GAP303/12/0576 GA ČR - Grantová agentura ČR 7AMB12FR011 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000342367600001 EID SCOPUS 84908131278 DOI https://doi.org/10.1186/1471-2202-15-111 Anotace Background: Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resistance and aging are risk factors for central insulin resistance and whether central insulin resistance is related to the pathologic phosphorylation of the Tau protein. Results: Aging and obesity significantly attenuated the phosphorylation of the insulin cascade kinases Akt (protein kinase B, PKB) and GSK-3 beta (glycogen synthase kinase 3 beta) in the hippocampi of the fa/fa rats. Furthermore, the hyperphosphorylation of Tau Ser396 alone and both Tau Ser396 and Thr231 was significantly augmented by aging and obesity, respectively, in the hippocampi of these rats. Conclusions: Both age-induced and obesity-induced peripheral insulin resistance are associated with central insulin resistance that is linked to hyperTau phosphorylation. Peripheral hyperinsulinemia, rather than hyperglycemia, appears to promote central insulin resistance and the Tau pathology in fa/fa rats. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2015
Počet záznamů: 1