Počet záznamů: 1
Recent Results in Cancer Research
- 1.
SYSNO ASEP 0428990 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Measurement of Protein Synthesis: In Vitro Comparison of 68Ga-DOTA-Puromycin, [3H]Tyrosine, and 2-Fluoro-[3H]tyrosine Tvůrce(i) Eigner, Sebastian (UJF-V) RID
Beckford, Denis R. (UJF-V) RID
Fellner, M. (DE)
Loktionova, N. (DE)
Piel, M. (DE)
Melichar, František (UJF-V) RID
Rosch, F. (DE)
Ross, T. L. (DE)
Lebeda, Ondřej (UJF-V) RID, ORCID, SAI
Eigner-Henke, Kateřina (UJF-V) RIDCelkový počet autorů 10 Zdroj.dok. Recent Results in Cancer Research, Theranostic, Gallium-68, and Other Radionuclides. - Berlin : Springer, 2013 / Baum Richard, P. - ISSN 0080-0015 - ISBN 978-3-642-27993-5 Rozsah stran s. 269-283 Poč.str. 15 s. Poč.výt. 250 Poč.str.knihy 578 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova puromycine ; Ga-68 ; molecular imaging ; PET ; proteosynthesis Vědní obor RIV FR - Farmakologie a lékárnická chemie CEP 2B06165 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA203/09/1056 GA ČR - Grantová agentura ČR Institucionální podpora UJF-V - RVO:61389005 EID SCOPUS 84867065779 DOI 10.1007/978-3-642-27994-2 Anotace Puromycin has played an important role in our understanding of the eukaryotic ribosome and protein synthesis. It has been known for more than 40 years that this antibiotic is a universal protein synthesis inhibitor that acts as a structural analog of an aminoacyl-transfer RNA (aa-tRNA) in eukaryotic ribosomes. Due to the role of enzymes and their synthesis in situations of need (DNA damage, e.g., after chemo- or radiation therapy), determination of protein synthesis is important for control of antitumor therapy, to enhance long-term survival of tumor patients, and to minimize side-effects of therapy. Multiple attempts to reach this goal have been made through the last decades, mostly using radiolabeled amino acids, with limited or unsatisfactory success. The aim of this study is to estimate the possibility of determining protein synthesis ratios by using 68Ga-DOTA-puromycin (68Ga-DOTA-Pur), [3H]tyrosine, and 2-fluoro-[3H]tyrosine and to estimate the possibility of different pathways due to the fluorination of tyrosine. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2015
Počet záznamů: 1