Počet záznamů: 1
Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver
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SYSNO ASEP 0396915 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver Tvůrce(i) Polidarová, Lenka (FGU-C) RID, ORCID
Sládek, Martin (FGU-C) RID, ORCID, SAI
Nováková, Marta (FGU-C)
Parkanová, Daniela (FGU-C)
Sumová, Alena (FGU-C) RID, ORCIDZdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 8, č. 9 (2013), e75690Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova circadian ; clock gene ; metabolism ; liver ; feeding regime ; Bmal2 ; spontaneously hypertensive rat Vědní obor RIV ED - Fyziologie CEP GAP303/11/0668 GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000325218700109 EID SCOPUS 84884554329 DOI 10.1371/journal.pone.0075690 Anotace Sensitivity of the circadian system to temporal change in feeding regime is higher in spontaneously hypertensive rats (SHR) than in controls. At the behavioral level, SHR develop faster food anticipatory activity than control rats and shift completely their locomotor activity rhythm. At the molecular level, their peripheral clock in the liver exhibits larger phase shift due to the change in feeding regime. The results suggested possible involvement of Bmal2 gene in the higher sensitivity of the SHR hepatic clock to the metabolic challenge Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2014
Počet záznamů: 1