Počet záznamů: 1
Carbohydrate Chemistry
- 1.
SYSNO ASEP 0395482 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Beta-N-Acetylhexosaminidases: group-specific inhibitors wanted Tvůrce(i) Slámová, Kristýna (MBU-M) RID, ORCID
Křen, Vladimír (MBU-M) RID, ORCIDZdroj.dok. Carbohydrate Chemistry. - Cambridge : The Royal Society of Chemistry, 2013 / Rauter A. P. ; Lindhorst K. T. - ISBN 978-1-84973-587-2 Rozsah stran s. 102-119 Poč.str. 18 s. Poč.výt. 1000 Poč.str.knihy 246 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova β-N-Acetylhexosaminidases: ; Alzheimer’s disease Vědní obor RIV CE - Biochemie CEP GP13-06818P GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 DOI 10.1039/9781849737173-00102 Anotace Beta-N-Acetylhexosaminidases (GH20) and β-N-acetylglucosaminidases (GH84) are two genetically and functionally unrelated classes of glycosidases sharing the substrate-assisted catalytic mechanism and architecture of their active sites. In humans, the deficiency of these enzymes causes severe neurodegenerative disorders (GH20) and Alzheimer’s disease (GH84). For the research of the physiological functions of these enzymes, inhibitors selective for just one of the enzyme families must be employed in order to avoid the generation of complex phenotypes. The search for highly potent and selective inhibitor sis based on the known common and distinct features of these enzyme groups, profiting from the crystal structures of the enzyme-inhibitor complexes. In this chapter, the most studied inhibitor scaffolds such as NAG-thiazoline, PUGNAc and GlcNAcstatins and their rationally designed analogues are described and discussed, providing an actual survey of the most efficient and selective compounds suitable for specific application Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2014
Počet záznamů: 1