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Antioxidative succinobucol-sterol conjugates: Crystal structures and pseudosymmetry in the crystals
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SYSNO ASEP 0380688 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Antioxidative succinobucol-sterol conjugates: Crystal structures and pseudosymmetry in the crystals Tvůrce(i) Ikonen, S. (FI)
Jurček, Ondřej (UEB-Q)
Wimmer, Zdeněk (UEB-Q) RID, ORCID
Drašar, P. (CZ)
Kolehmainen, E. (FI)Zdroj.dok. Journal of Molecular Structure. - : Elsevier - ISSN 0022-2860
Roč. 1011, Mar 2012 (2012), s. 25-33Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Probucol ; Steroid ; Phytosterol Vědní obor RIV CC - Organická chemie CEP OC10001 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy 2B06024 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000301316600005 DOI https://doi.org/10.1016/j.molstruc.2011.12.016 Anotace An extensive study to attach succinobucol to sterols has provided conjugates which comprise two pharmaceutically important compounds into one entity where the components are expected to have a synergistic effect. The motivation to design these novel conjugates was the need to broaden the armamentarium of current agents used in the treatment of atherosclerotic diseases and type 2 diabetes. In desire for detailed information of these compounds in solid state, which also have an influence to their physiological activity, systematic crystallization experiments were performed and as a result, X-ray quality single crystals were obtained from four succinobucol–sterol conjugates. All of these compounds crystallized in space group P1 with two or four molecules in an asymmetric unit and the crystallographically independent molecules were found to be related by pseudosymmetry (i.e. by pseudoinversion in 1–3 and by pseudoinversion plus pseudotranslation in 4). Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2013
Počet záznamů: 1