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Tick salivary secretion as a source of antihemostatics
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SYSNO ASEP 0377619 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Tick salivary secretion as a source of antihemostatics Tvůrce(i) Chmelař, Jindřich (BC-A)
Calvo, E. (US)
Pedra, J. H. F. (US)
Francischetti, I.M.B. (US)
Kotsyfakis, Michalis (BC-A) RID, ORCIDZdroj.dok. Journal of Proteomics. - : Elsevier - ISSN 1874-3919
Roč. 75, č. 13 (2012), s. 3842-3854Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Tick ; Salivary gland ; Hemostasis ; Coagulation ; Platelet aggregation ; Thrombin Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP502/12/2409 GA ČR - Grantová agentura ČR CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000307025100004 DOI 10.1016/j.jprot.2012.04.026 Anotace Ticks are mostly obligatory blood feeding ectoparasites that have an impact on human and animal health. In addition to direct damage due to feeding, some tick species serve as the vectors for the causative agents of several diseases, such as the spirochetes of the genus Borrelia causing Lyme disease, the virus of tick-borne encephalitis, various Rickettsial pathogens or even protozoan parasites like Babesia spp. Hard ticks are unique among bloodfeeders because of their prolonged feeding period that may last up to two weeks. During such a long period of blood uptake, the host develops a wide range of mechanisms to prevent blood loss. The arthropod ectoparasite, in turn, secretes saliva in the sites of bite that assists blood feeding. Indeed, tick saliva represents a rich source of proteins with potent pharmacologic action that target different mechanisms of coagulation, platelet aggregation and vasoconstriction. Tick adaptation to their vertebrate hosts led to the inclusion of a powerful protein armamentarium in their salivary secretion that has been investigated by high-throughput methods. The resulting knowledge can be exploited for the isolation of novel antihemostatic agents. Here we review the tick salivary antihemostatics and their characterized functions at the molecular and cellular levels. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2013 Elektronická adresa http://www.sciencedirect.com/science/article/pii/S187439191200245X
Počet záznamů: 1