Počet záznamů: 1
Cancer Stem Cells Theories and Practice
- 1.
SYSNO ASEP 0375203 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Drugs that kill cancer stem-like cells Tvůrce(i) Zobalová, Renata (BTO-N) RID
Stantic, M. (AU)
Stapelberg, M. (AU)
Prokopová, Kateřina (BTO-N) ORCID
Dong, L.F. (AU)
Truksa, Jaroslav (BTO-N) RID, ORCID
Neužil, Jiří (BTO-N) RIDZdroj.dok. Cancer Stem Cells Theories and Practice. - Rijeka : InTech, 2011 / Shostak Stanley - ISBN 978-953-307-225-8 Rozsah stran s. 1-442 Poč.str. 18 s. Poč.výt. 1000 Poč.str.knihy 442 Jazyk dok. eng - angličtina Země vyd. HR - Chorvatsko Klíč. slova Cancer stem cells ; 2,3-dioxygenase ; MitoVES ; inhibitors of indoleamine Vědní obor RIV CE - Biochemie CEZ AV0Z50520701 - BTO-N (2007-2013) Anotace A review desribes mechanisms by which a host of agents kill (or fail to kill) CSCs. The authors characterize three types of CSCs, namely, breast and prostate cancer and mesothelioma cultured as cancer cell spheres in vitro. The analysis of their stemness is then taken to a new plane by using microarray analysis and the tools of bioinformatics. The tryptophan pathway was the most activated of all pathways whose activation was common to the cancer cells studied suggesting that inhibitors of indoleamine-2,3-dioxygenase (IDO), an enzyme in the tryptophan to N-formyl kynurenin pathway, would be useful for killing CSCs. The authors then develop the principle of mitochondrial targeting by synthesizing a mitochondrially targeted vitamin E succinate [MitoVES] that crosses the mitochondrial inner membrane and acts by targeting the mitochondrial complex II. MitoVES is probably thus far the best characterized agent toxic to CSCs. Two-pronged approach to therapy, therefore, might be desirable. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1