Počet záznamů: 1
Molecular Changes Induced by the Teratogenic Environment of Maternal Diabetes in Embryonic Hearts
- 1.
SYSNO ASEP 0372378 Druh ASEP C - Konferenční příspěvek (mezinárodní konf.) Zařazení RIV Záznam nebyl označen do RIV Název Molecular Changes Induced by the Teratogenic Environment of Maternal Diabetes in Embryonic Hearts Tvůrce(i) Pavlínková, Gabriela (BTO-N) RID, ORCID
Bohuslavová, Romana (BTO-N) RID
Kuthanová, Lada (BTO-N)
Sedmera, David (FGU-C) RID, ORCID, SAI
Bloudičková, Sylvie (BTO-N)Zdroj.dok. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY. - MALDEN : WILEY-BLACKWELL, 2011 - ISSN 1542-9768 Rozsah stran s. 339-339 Akce 51th Annual Meeting of the Teratology Society Datum konání 25.06.2011-29.06.2011 Místo konání San Diego, California Země US - Spojené státy americké Typ akce WRD Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Diabetic embryopathy ; cardiovascular defects ; expression profiling Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000290494900063 Anotace Although teratogenic effects of maternal diabetes are well documented, the causes remain elusive. We hypothesize that HIF1a-controlled hypoxia-response pathways are critically involved in the susceptibility to congenital defects observed in diabetic embryopathy. We have analyzed the frequencies and morphology of congenital defects and changes in the expression of HIF1 target genes in Hif1a+/- and wildtype (wt) embryos exposed to maternal diabetes. The Hif1a+/- embryos from diabetic pregnancy showed an increased rate of cardiovascular defects of 62.5% as compared to 36.8% of wt diabetes-exposed embryos with a range of cardiac malformations. We also detected significant changes in the gene expression in diabetes-exposed Hif1a+/- embryos as compared to diabetes-exposed wt. Limiting levels of Hif1α has compromised embryonic development under the conditions of maternal diabetes. Our data strongly suggest that HIF1-activated pathways could be one of the key molecular pathways in the pathogenesis of diabetes-induced congenital defects. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1