Počet záznamů: 1
Daxx inhibits stress-induced apoptosis in cardiac myocytes
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SYSNO ASEP 0325125 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Daxx inhibits stress-induced apoptosis in cardiac myocytes Překlad názvu Daxx inhibuje apoptózu indukovanou stresem v kardiomyocytech Tvůrce(i) Zobalová, Renata (BTO-N) RID
Swettenham, E. (AU)
Chladová, Jaromíra (BTO-N) RID
Dong, L.F. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Redox Report. - : Taylor & Francis - ISSN 1351-0002
Roč. 13, č. 6 (2008), s. 263-270Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Daxx ; apoptosis ; oxidative stress Vědní obor RIV EB - Genetika a molekulární biologie CEP GA305/07/1008 GA ČR - Grantová agentura ČR CEZ AV0Z50520701 - BTO-N (2007-2013) Anotace The role of the death-associated protein Daxx in modulation of apoptosis induced in cardiac myocytes by oxidative stress was studied. Exposure of cardiomyocyte-like cells to oxidative stress or simulated hypoxia increased the level of accumulated ROS and apoptosis. Under conditions of sub-apoptotic stimulation of cardiac myocytes, there was no increase in the level of the Daxx protein, but it translocated from the nucleus to the cytoplasm. Daxx overexpression protected the cells from apoptosis, while they were sensitised to cell death following its down-regulation by siRNA. Lowering the level of the Daxx protein sensitised cardiac myocytes to spontaneous apoptosis, suggesting that the protein may also have a prosurvival role under physiological conditions. Finally, it was shown that DJ-1, a protein suggested previously to sequester Daxx in the nucleus under conditions of oxidative stress preventing thus its cytosolic translocation, was localised in the cytoplasm of cardiac myocytes Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2009
Počet záznamů: 1